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Journal of the Mexican Chemical Society
versão impressa ISSN 1870-249X
Resumo
ABASS, Mohamed; ISMAIL, Mostafa M.; ABDEL-MONEM, Wafaa R. e MAYAS, Aisha S.. Substituted Pyridopyrimidinones. Part 3.: Synthesis of Some Novel Ether Derivatives of 4H-Pyrido[1,2-a]pyrimidin-4-one. J. Mex. Chem. Soc [online]. 2009, vol.53, n.2, pp.48-54. ISSN 1870-249X.
A series of novel bis-heterocyclic ethers, containing 4H-pyrido[1,2-a]pyrimidin-4-one along with other five and six-membered heterocyclic rings, was obtained utilizing ethyl [(4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)oxy]acetate (1), [(4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)oxy]acetic acid (2) and/or [(4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)oxy]acetohydrazide (3). Reaction of ester 1 with some ortho-hydroxy-aldehydes furnished the corresponding pyrido-pyrimidyloxypyrones. Reaction of ester 1 or acid 2 with 1,2-diamines led to some imidazoles. Also, some pyrazole, triazole, and oxadiazoline derivatives have been prepared from hydrazide 3.
Palavras-chave : Pyrido[1 ,2-a] pyrimidinone; Ethers; Pyrazoles; Oxadiazolines; Pyrones.