Abstract

HERNANDEZ LINARES, Guadalupe et al. Synthesis and Absolute Configuration of (20R)-20-Acetyl-23,24-bisnorcholanic Lactones Prepared from (E)-(20S,25R)- and (E)-(20S,25S)-20,23-Diacetylfurost-22-enes. J. Mex. Chem. Soc [online]. 2007, vol.51, n.4, pp.217-221. ISSN 1870-249X.

The synthesis of (20R)-20-acetyl-23,24-bisnorcholanic lactones from (E)-(20S,25R)- and (E)-(20S,25R)-20,23-diacetylfurost-22-enes (derived from diosgenin, hecogenin and sarsasapogenin) is reported. The configuration of the stereogenic center at C-20 was determined by NMR and single crystal X-ray diffraction studies. The lactones can be used in the synthesis of a variety of steroidal derivatives.

Keywords : Absolute configuration; 23,24-bisnorcholanic lactones; 20,23-diacetylfurost-22-enes; molecular structure.

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