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Journal of the Mexican Chemical Society

Print version ISSN 1870-249X


SORIA-ARTECHE, Olivia et al. Studies on the Selective S-oxidation of Albendazole, Fenbendazole, Triclabendazole, and Other Benzimidazole Sulfides. J. Mex. Chem. Soc [online]. 2005, vol.49, n.4, pp.353-358. ISSN 1870-249X.

The selective S-oxidation of albendazole, fenbendazole, and other benzimidazole sulfides with sodium periodate in acid medium, afforded the corresponding sulfoxides or sulfones. In contrast, triclabendazole and other 2-methylthiobenzimidazole derivatives could not be S-oxidized under the same smooth conditions with this reagent, but with MCPBA, a stronger oxidizing agent.

Keywords : Albendazole; fenbendazole; triclabendazole; metabolites; S-oxidation.

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