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vol.49 issue2A Mild and Efficient Method for the Chemoselective Synthesis of Acylals from Aromatic Aldehydes and their Deprotections Catalyzed by Sulfated Zirconia author indexsubject indexsearch form
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Journal of the Mexican Chemical Society

Print version ISSN 1870-249X


DE FATIMA, Ângelo; LAPIS, Alexandre Augusto M.  and  PILLI, Ronaldo A.. A Concise Total Synthesis of (R)-Fluoxetine, a Potent and Selective Serotonin Reuptake Inhibitor. J. Mex. Chem. Soc [online]. 2005, vol.49, n.2, pp.257-261. ISSN 1870-249X.

(R)-Fluoxetina, um inibidor potente e seletivo da recaptação da serotonina, foi sintetizada em seis etapas, 50% de rendimento total e 99% de excesso enantiomérico a partir do benzaldeído via alilação catalítica assimétrica empregando-se o sistema catalítico desenvolvido por Maruoka e colaboradores.

Keywords : fluoxetine; serotonin reuptake inhibitor; catalytic asymmetric allylation.

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