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Journal of the Mexican Chemical Society

Print version ISSN 1870-249X


DE FATIMA, Ângelo; LAPIS, Alexandre Augusto M.  and  PILLI, Ronaldo A.. A Concise Total Synthesis of (R)-Fluoxetine, a Potent and Selective Serotonin Reuptake Inhibitor. J. Mex. Chem. Soc [online]. 2005, vol.49, n.2, pp.257-261. ISSN 1870-249X.

(R)-Fluoxetine, potent and selective serotonin reuptake inhibitor, has been synthesized in six steps, 50% overall yield and 99% ee from benzaldehyde via catalytic asymmetric allylation with Maruoka's catalyst.

Keywords : fluoxetine; serotonin reuptake inhibitor; catalytic asymmetric allylation.

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