Abstract

NEGRON, Guillermo E. et al. A Mild and Efficient Method for the Chemoselective Synthesis of Acylals from Aromatic Aldehydes and their Deprotections Catalyzed by Sulfated Zirconia. J. Mex. Chem. Soc [online]. 2005, vol.49, n.2, pp.252-256. ISSN 1870-249X.

Aldehydes can be converted to acylals by treatment with acetic anhydride in the presence of sulfated zirconia in excellent yield at 0^°C. Ketones and aliphatic aldehydes are found to be unaffected under the reaction conditions. The deprotection of the resulting acylals is achieved using the same catalyst at 60 ^oC. The catalyst can be reused in two cycles without losing its activity.

Keywords : acylals; sulfated zirconia; protection; deprotection.

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