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Journal of the Mexican Chemical Society

Print version ISSN 1870-249X


ANTONOW, Dyeison et al. Synthesis of 2,4-Disubstituted Thiazole Combinatorial Unit on Solid-Phase: Microwave Assisted Conversion of Alcohol to Amine Monitored by FT-IR. J. Mex. Chem. Soc [online]. 2005, vol.49, n.2, pp.239-243. ISSN 1870-249X.

Microwave-assisted solid-phase synthesis of the 2,4-disubstituted thiazole 3 on Merrifield Resin is described. The hydroxyl moiety was converted to amine in five steps - including coupling and cleavage - within a total reaction time of 2 hours and 26% overall yield. The entire solid-phase synthesis was efficiently monitored by FT-IR/KBr pellets and allows potential use in combinatorial chemistry.

Keywords : thiazole; microwave; monitoring solid-phase reactions.

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