Abstract

GORDON-NUNEZ, Manuel Antonio; BARROS, Simone Souza Lobão Veras; FERNANDEZ, María Zélia  and  PINTO, Leão Pereira. Spontaneous oral bleeding in children with malignant neoplasm. Its relation with trombocytopenia. Rev. Odont. Mex [online]. 2006, vol.10, n.4, pp.162-166. ISSN 1870-199X.  https://doi.org/10.22201/fo.1870199xp.2006.10.4.15890.

Several studies have demonstrated the association of thrombocytopenia with the occurrence of bleeding in patients with malignant neoplasia, immunosuppressive states or the use of anticoagulant medicine. In this paper we evaluated the occurrence of spontaneous bleeding in 40 children with malignant neoplasia and its relation between this disease verifying its relation to this oral complication, the type of neoplasm, treatment and platelet counts. Two children with acute lymphoblastic leukemia and 4 with acute myelogenous leukemia developed 10 episodes of spontaneous oral bleeding, mainly in gingival areas, coinciding most of them with thrombocytopenic states. The Fisher's exact test does not show significant difference in the occurrence of spontaneous oral bleeding between children with systemic neoplasm and solid tumours (p = 0.067); nevertheless, statistically, children with systemic neoplasm and thrombocytopenia had a higher risk of presenting this complication (OR = 10.93 y OR = 8.077 respectively). The bleeding coincided with the use of methotrexate and cytarabine. It was concluded that the risk of spontaneous oral bleeding in children with malignant neoplasm is higher, mainly in children with systemic neoplasm. On the other hand, the occurrence of spontaneous oral bleeding can be considered as an early sign of thrombocytopenia in these patients.

Keywords : Systemic neoplasm; solid tumours; thrombocytopenia; spontaneous oral bleeding.

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