Resumen

MALDONADO SAAVEDRA, Octavio et al. Cholesterol: Biological function and medical implications. Rev. mex. cienc. farm [online]. 2012, vol.43, n.2, pp.7-22. ISSN 1870-0195.

Our body synthesizes its own cholesterol, an extra percentage is obtained from diet. Cholesterol is part of our cell membranes, serves as a precursor of all steroid hormones, bile acids, and vitamin D. Excessive intake of cholesterol and genetic mutations in the rLDL promotes the increase of blood serum cholesterol above recommended levels, which facilitate the genesis of atherosclerosis, that is the main risk factor for developing cardiovascular disease. Healthy lifestyles, dietary and pharmacological treatments are able to reduce plasma cholesterol concentrations, which decreases the probability to suffer a coronary event. Here, we review the biological role of cholesterol, its relationship with cardiovascular disease also discusses dietary and pharmacological aspects help to counteract these conditions.

Palabras llave : cholesterol; hypercholesterolemia; endothelial dysfunction; atherosclerosis; cardiovascular disease.

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