Resumen

FUENTES DELGADO, Víctor Hugo et al. Acute and chronic hepatotoxicity produced by methyl parathion pesticide in the rat. Rev. mex. cienc. farm [online]. 2011, vol.42, n.3, pp.50-56. ISSN 1870-0195.

Methyl parathion (PM) is an organophosphate pesticide widely used in agriculture. In the human it is absorbed through different routes. In this work, we investigated the liver damage induced by PM in male Wistar rats. At the subacute exposition (3 mg/kg/day, oral, 20 days) there were a significant increase (p<0.05) in the serum activities of GOT (500 %) and GPT (937 %), hepatic necrosis, the malondialhdeyde concentration significantly increased (213 %) and the ATP concentration decreased (29.3 %) in the liver. At the chronic exposition (0.56 mg/kg/day, oral, 6 weeks) there was an extensive vacuolization in the hepatocytes (lipid accumulation), mainly in the central lobe area of the liver. We concluded that PM produces hepatic oxidative damage and necrosis in the subacute exposition as well as structural damage in the chronic exposition.

Palabras llave : methyl parathion; organophosphate pesticides; oxidative stress; hepatic damage.

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