Resumo

RIVERA-CASTANO, Leopoldo. Obstructive sleep apnea (OSA) should be considered a comorbidity as a risk factor for COVID-19 fatality: A review. Part II. Rev. mex. neurocienc. [online]. 2021, vol.22, n.4, pp.159-172.  Epub 30-Jul-2021. ISSN 2604-6180.  https://doi.org/10.24875/rmn.20000122.

The COVID-19 outbreak caused by the SARS-CoV-2 virus turned into a pandemic and from the first reported cases in December 2019-December 31, 2020, more than 82 million positive cases have been reported with a cumulative fatality of 1,806,155 people due to the complication of a mild upper respiratory infection to a severe lower respiratory disease, such as acute respiratory distress syndrome, and death from multiple organ failure. Comorbidities such as obstructive sleep apnea (OSA) that have a high prevalence in older adults with obesity, should be considered as an additional risk factor for fatality, due to endothelial dysfunction secondary to hypoxia coupled with an increase in the inflammatory cascade with dysfunction of the glymphatic system during sleep in response to SARS-CoV-2.

Palavras-chave : OSA; COVID-19; Comorbidities; Risk factors.

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