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Revista mexicana de neurociencia

versão On-line ISSN 2604-6180versão impressa ISSN 1665-5044


RUIZ-SANDOVAL, José L. et al. Symptomatic palatal tremor: A descriptive cohort study of 27 cases in a tertiary hospital. Rev. mex. neurocienc. [online]. 2020, vol.21, n.5, pp.199-204.  Epub 30-Jul-2021. ISSN 2604-6180.


Symptomatic palatal tremor (SPT) is an uncommon hyperkinetic movement disorder caused by the interruption of the dentato-rubro-olivary pathway due to a lesion in the brainstem or cerebellum.


We describe a cohort of consecutive patients with SPT who were assessed by a single neurologist in a tertiary reference center.


A total of 27 patients were included in this cohort from 1998 to 2016; 16 males and 11 females, with a mean age of 47 years (range 19-89). The average time from initial insult to a diagnosis of SPT was 14.5 months (range 2-48 months). The most common etiology of SPT was cerebrovascular disease (CVD) in 21 (78%) patients. Other etiologies included infectious and demyelinating diseases of the central nervous system. The remaining unclassified case was accompanied by progressive ataxia pointing toward a neurodegenerative etiology. Twenty-six patients had a history of posterior fossa injury, and all patients had rhombencephalic signs with severe dysarthria. None of them responded significantly to pharmacological treatment.


SPT is a more common finding than expected, especially in patients with posterior fossa injury secondary to CVD. The main clinical syndrome was the rhomboencephalic phenotype, with a predominance of dysarthria. There was no effective treatment in any of the patients.

Palavras-chave : Dysarthria; Guillain–Mollaret triangle; Hyperkinetic movement disorders; Palatal tremor; Rhomboencephalic syndrome.

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