Abstract

ESTRADA-ROJO, Francisco; ESCOBAR, Carolina  and  NAVARRO, Luz. Circadian variations of neurotransmitters in the brain – Its importance for neuroprotection. Rev. mex. neurocienc. [online]. 2020, vol.21, n.1, pp.31-38.  Epub Mar 22, 2022. ISSN 2604-6180.  https://doi.org/10.24875/rmn.19000069.

Circadian rhythms are expressed at the biochemical, physiological, and behavioral level; they help to maintain the internal temporal order of an organism and allow adaptation to a cyclical environment. Circadian rhythms have a substrate at the genetic level and are synchronized to geographical cycles, as well as to other external factors, of which the main one is the light–dark cycle. Cerebral functions present circadian rhythms, which influence the neuroprotective response to acquired brain damage, such as a traumatic brain injury (TBI). Knowing the moments of greatest vulnerability to such events will allow us to offer elements to develop better study models and therapeutic objectives. Here, we present a review on diurnal variation in the levels of noradrenaline, histamine, orexin, glutamate, gamma-aminobutyric acid, serotonin, acetylcholine (ACh), and dopamine, as well as in the expression of their receptors in the brain, neurotransmission systems that may be involved in neuroprotective responses to a TBI.

Keywords : Diurnal variation; Traumatic brain injury; Biological rhythms; Neuroprotection.

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