Abstract

GARZON, M. de L.; TECANTE, A.; RAMIREZ-GILLY, M.  and  PALACIOS, J.. Viscoelastic behavior of solutions and hydrated tablets of individual hydroxypropylmethylcellulose, sodium carboxymethylcellulose, and their mixtures. Rev. Mex. Ing. Quím [online]. 2009, vol.8, n.3, pp. 307-318. ISSN 1665-2738.

The rheological properties of hydrophilic pharmaceutical polymers used for oral solid dosage forms could have an effect on the kinetics of drug release when they come in contact with gastrointestinal fluids. Hydroxypropylmethylcellulose (HPMC) and sodium carboxymethylcellulose (CMCNa) are common ingredients of pharmaceutical drug tablets. Therefore, the viscoelastic behavior of solutions and hydrated tablets of the individual polymers and their mixtures was studied at different pHs. The viscoelastic behavior of solutions and tablets was different, but it was pH dependent. At pH 1.3 the largest differences were observed. Gelation was not observed in any of the examined samples.

Keywords : cellulose; hydrophilic polymers; gels; tablets; viscoelasticity.