Abstract

VIDAL GUTIERREZ, Max et al. Antioxidant and antiproliferative activity of six medicinal plants from northwestern Mexico. Biotecnia [online]. 2020, vol.22, n.3, pp.40-45.  Epub Feb 10, 2021. ISSN 1665-1456.  https://doi.org/10.18633/biotecnia.v22i3.1169.

Reactive oxygen species, which induce oxidative stress in the body, are one of the risk factors for some cancer types. In Mexico, the types of cancer with the highest mortality are prostate, breast, cervical, lung, and liver. Natural products represent the oldest form of medicinal remedies; for cancer, this source is no exception. In this investigation, we studied the antiproliferative activities, by MTT, and the antioxidant activity, by ABTS and DPPH, in six northwestern Mexico medicinal plants. The Jacquinia macrocarpa ssp. pungens fruit shells showed the best antiproliferative activity with an IC50 of 9.2 µg/mL in A549, followed by Bursera microphylla with IC50 13.8 µg/mL in HeLa. Bursera laxiflora showed the best antioxidant activity of the six plants against ABTS and DPPH radicals, and also presented antiproliferative activity in HeLa. The bark of B. laxiflora contains compounds with antioxidant activities, which are probably also the same that induce antiproliferative activity in cancer cell lines. On the other hand, J. macrocarpa showed no antioxidant activity. However, the three species of plants represent a potential source of molecules with antiproliferative activity.

Keywords : Antiproliferative activity; Antioxidant activity; Bursera; Jacquinia; Acacia.

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