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Boletín médico del Hospital Infantil de México
versión impresa ISSN 1665-1146
Resumen
GIRALDO-GRUESO, Manuel; VILLEGAS, María C.; RODRIGUEZ, David L. y RODRIGUEZ, Edison. Langerhans cell histiocytosis with vertebral involvement. Bol. Med. Hosp. Infant. Mex. [online]. 2018, vol.75, n.5, pp.309-312. ISSN 1665-1146. https://doi.org/10.24875/bmhim.m18000024.
Background:
Langerhans cell histiocytosis (LCH) is a rare disease, more common in the first three years of lite. lt is characterized by single ar multiple osteolytic lesions due to clonal proliferation of cells histologically similar to Langerhans cells; its clínical presentation is heterogeneous.
Case report:
7-year-old female patient with 5 days of progressive lower extremity weakness and difficulty to walk. Physical exam findings were consistent with pyramidal syndrome and lower extremities hypoesthesia. Magnetic resonance imaging (MRI) of spine and cranial computed tomography (CT) were performed. lntracranial pathology was ruled out. The MRI findings showed vertebra plana with epidural and paravertebral involvement, so treatment with steroids and surgical decompression initiated. Partíal resection and biopsy of the lesion was performed. Due to histological findings and positive CD1a and CD207 markers, diagnosis of LCH was confirmed.
Conclusions:
LCH is an uncommon disease with a challenging diagnosis due to its heterogeneous clinical presentation. Eosinophilic granuloma and vertebra plana as imaging findings may guide the diagnosis. However, it should always be confirmed with histological evidence.
Palabras llave : Langerhans cell histiocytosis; Granuloma; Spinal injury.