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Boletín médico del Hospital Infantil de México

versión impresa ISSN 1665-1146

Resumen

CANTU REYES, Jorge Alberto et al. Experience with OK-432 in lymphatic vascular malformations in a hospital from northern Mexico. Bol. Med. Hosp. Infant. Mex. [online]. 2018, vol.75, n.2, pp.89-93. ISSN 1665-1146.  http://dx.doi.org/10.24875/bmhim.m18000013.

Abstract

Background:

Lymphatic vascular malformations (LVM) or formerly called lymphangiomas are congenital malformations present in about 1 out of 6000 to -16000 births. The most relevant classification system for lymphangioma management is based on the size of the cysts. Spontaneous resolution is uncommon; thus, expectant management is not recommended. The classic treatment is excisional surgery, but it can affect adjacent structures or have relapses, so, sclerosing substances like OK-432 are being studied. The majority of the studies are small in number of patients and are from Japan; the largest studies in Mexico are focused on specific lesions (macrocystic) or a determined anatomical region. To date, there are no studies of the population of the north of Mexico.

Methods:

The experience with OK-432 was described through a retrospective, descriptive study in patients with LVM, from 2011 to 2016, in a reference hospital of northern Mexico.

Results:

A total of 26 patients with LVM were treated with OK-432. The majority of the lesions were macrocystic (69 %), microcystic (19 %) and mixed (12 %). From the total number of patients, 11 fully healed, and 72 % of the study population had >50 % reduction in lesion size, with only 2 applications. There were no recurrences. Complications were reported in 2 patients who had skin hyperpigmentation.

Conclusions:

OK-432 probed to be an effective treatment for LVM in a reference hospital in the north of Mexico.

Palabras llave : OK-432; Lymphangioma; Sclerotherapy.

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