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Boletín médico del Hospital Infantil de México
versión impresa ISSN 1665-1146
Resumen
QUINONES-VAZQUEZ, Susana; LIRIANO-RICABAL, María del Rosario; SANTANA-PORBEN, Sergio y SALABARRIA-GONZALEZ, José Reinaldo. Calcium-creatinine ratio in a morning urine sample for the estimation of hypercalciuria associated with non-glomerular hematuria observed in children and adolescents. Bol. Med. Hosp. Infant. Mex. [online]. 2018, vol.75, n.1, pp.41-48. ISSN 1665-1146. https://doi.org/10.24875/bmhim.m18000006.
Background:
Hypercalciuria might be revealed during the differential diagnosis of hematuria accompanying renal lithiasis (RL). In spite of this, diagnostic accuracy of calcium urinary excretion might be affected by incomplete 24-hour urine collections. In the present study, the diagnostic utility of calcium/creatinine (ICaCre) index for determining hypercalciuria associated with non-glomerular hematuria (NGH) and RL was assessed.
Method:
ICaCre (mg/mg) index was calculated from calcium (mmol/l) and creatinine (µmol/l) concentrations in an aliquot from a 24-hour urine collection in 169 children and adolescents with NGH or RL. Calciuria values > 4.0 mg/kg in 24 hours were distributed according to the presence of NGH or RL.
Results:
Mean ICaCre index was 0.2 ± 0.1 mg/mg. Calciuria values estimated from ICaCre were statistically higher to those from 24-hour urine collection (p < 0.05). The frequency of hypercalciuria was independent from the measurement method (estimated from ICaCre 39.5% vs. 24 h collection 32.1%; p > 0.05). Hypercalciuria distribution was as follows: no NGH + no RL: 59.0%; no NGH + RL: 60.0% (∆ = +1.0%); NGH + no RL: 68.2% (∆ = +9.2%); NGH + RL: 73.3% (∆ = +14.4%).
Conclusions:
The use of ICaCre index for determining calcium urine excretion might be effective in the study of hypercalciuria associated with NGH and RL.
Palabras llave : Hypercalciuria; Urine; Hematuria; Kidney litiasis.