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Boletín médico del Hospital Infantil de México
versión impresa ISSN 1665-1146
Resumen
VALLE-LEAL, Jaime et al. Active form of vitamin D in overweight and obese pediatric patients in northwest Mexico. Bol. Med. Hosp. Infant. Mex. [online]. 2017, vol.74, n.6, pp.413-418. ISSN 1665-1146. https://doi.org/10.1016/j.bmhimx.2017.07.004.
Background:
Low levels of vitamin D have been associated with a range of clinical conditions such as obesity, insulin resistance, and diabetes mellitus, among others. There are few studies that measure the active form of vitamin D (1,25 (OH)2 vitamin D) in obese children. However, published data are inconclusive. The aim of this study was to determine the active levels of vitamin D in obese and overweight children and to find an association between low levels of vitamin D, obesity and impaired glucose metabolism.
Methods:
A cross-sectional, analytical study was conducted in 6 to 12-year-old children with excess adiposity determined by waist-stature index and body mass index. Levels of glucose, insulin, complete lipid profile, homeostatic model assessment and the active form of vitamin D were measured in each patient. Levels < 30 pg/ml were considered as low levels of vitamin D.
Results:
The prevalence of low levels of active vitamin D was 36%. A significant association between low levels of active vitamin D and high levels of insulin was found. No significant association was found between vitamin levels and adiposity measures.
Conclusions:
Low levels of active vitamin D were found in 36% of the population studied. A significant association with insulin resistance and hyperinsulinemia was demonstrated.
Palabras llave : Childhood obesity; 1,25 (OH)2 vitamin D; Insulin resistance; Abdominal obesity.