Abstract

MANZANARES-MEZA, Laura Denise; GUTIERREZ-ROMAN, Claudia Ivonne  and  MEDINA-CONTRERAS, Oscar. MALDI imaging: beyond classic diagnosis. Bol. Med. Hosp. Infant. Mex. [online]. 2017, vol.74, n.3, pp.212-218. ISSN 1665-1146.  https://doi.org/10.1016/j.bmhimx.2017.03.004.

Mass spectrometry has been the focus of technology development and application for imaging for several decades. Imaging mass spectrometry using matrix-assisted laser desorption ionization is a new and effective tool for molecular studies of complex biological samples such as tissue sections. As histological features remain intact throughout the analysis of a section, distribution maps of multiple analytes can be correlated with histological and clinical features. Spatial molecular arrangements can be assessed without the need for target-specific reagents, allowing the discovery of diagnostic and prognostic markers of different cancer types and enabling the determination of effective therapies.

Keywords : Mass spectrometry; Imaging; MALDI.

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