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Boletín médico del Hospital Infantil de México

versión impresa ISSN 1665-1146


LEE, Tae-Hee  y  KO, Young-Hyeh. Chronic active EBV infection: the experience of the Samsung Medical Center in South Korea. Bol. Med. Hosp. Infant. Mex. [online]. 2016, vol.73, n.1, pp.10-17. ISSN 1665-1146.


Chronic active EBV infection (CAEBV) of T-cell or NK-cell type is an EBV+ polyclonal, oligoclonal or often monoclonal lymphoproliferative disorder (LPD) recognized as representing the spectrum of EBV-associated T-cell and NK-cell LPD with different clinical presentations; one systemic and two cutaneous disorders including hydroa vacciniforme-like T-cell LPD and mosquito bite hypersensitivity. The systemic form of the disease is characterized by fever, persistent hepatitis, hepatosplenomegaly and lymphadenopathy, which shows varying degrees of clinical severity depending on the immune response of the host and the EBV viral load.

Case reports:

We described the clinicopathological findings of two children with CAEBV with a brief review of the literature.


Recognition of the disease is important for adequate management of the patient. EBV analysis should be included in the principal diagnostic tests for febrile children.

Palabras llave : Epstein-Barr virus; Children; Chronic active infection; NK lymphocytosis; Mosquito-bite hypersensitivity.

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