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Boletín médico del Hospital Infantil de México

versión impresa ISSN 1665-1146


CASTILLA-PEON, María Fernanda; RAMIREZ-SANDOVAL, Juan C.; REYES-MORALES, Hortensia  y  REYES-LOPEZ, Alfonso. Clinical research design and causality: does oral rotavirus vaccine cause intussusception?. Bol. Med. Hosp. Infant. Mex. [online]. 2015, vol.72, n.5, pp.346-352. ISSN 1665-1146.

Design of clinical research whose purpose is to answer questions about causality can be classified in relation to four axes: the number of study groups, the implementation of an experimental maneuver, cause-effect directionality and source from which the data are collected. The basic designs used in epidemiology are the clinical trial, the cohort study, the case-control study and the cross-sectional survey. This text aims to facilitate the identification and understanding of each of these designs through examples related to the association between rotavirus vaccination and intussusception.

Palabras llave : Research designs; Causality; Clinical trial; Cohort; Case-control; Cross-sectional.

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