SciELO - Scientific Electronic Library Online

vol.66 número6Consumo de refrescos y riesgo de obesidad en adolescentes de Guadalajara, MéxicoHidropesía fetal no inmune: Informe de un caso índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




Links relacionados

  • No hay artículos similaresSimilares en SciELO


Boletín médico del Hospital Infantil de México

versión impresa ISSN 1665-1146


DIAZ-JAIMES, Ernesto; PENALOZA-OCHOA, Laura  y  PARADA-ONOKO, Patricia Midory. Electrophysiological changes of peripheral neuropathy with vincristine after a physical therapy program in pediatric patients with acute lymphoblastic leukemia. Bol. Med. Hosp. Infant. Mex. [online]. 2009, vol.66, n.6, pp.529-536. ISSN 1665-1146.

Background: Vincristine is among the drugs used for the treatment of patients with acute lymphoblastic leukemia (ALL). Because it is time- and dose-dependent, it is a drug whose most-feared effect is affectation of the peripheral nerves. It produces long-term physical incapacity that limits activities of daily living. We undertook this study to demonstrate that ALL patients who were enrolled in a supervised program of physical therapy presented confirmed improvement using the nerve conduction velocity (NCV) test of motor and sensorial nerves. Methods: This was an experimental, comparative, longitudinal, and prospective study carried out in the Department of Rehabilitation of the Hospital Infantil of Mexico <<Federico Gomez.>> Twenty four patients who fulfilled the inclusion criteria were included. Patients were divided into two groups: group 1-supervised group who received a program of regular, supervised physical therapy for 3 months and group 2-unsupervised group who received a regular program of physical therapy. In both groups, NCV studies were carried out prior to and subsequent to the physical therapy regime. Latency, amplitude and NCV of sensorial and motor nerves of the four extremities were compared. Results: The peroneal nerve was affected in 98% of the cases and axonal degeneration was the most frequent neuropathy appearing in 96% of subjects. Relationship of the results obtained in the NCV studies (both prior and subsequent) in both groups was statistically nonsignificant (P >0.01), whereas the relationship of the NCV studies between groups was statistically significant (P <0.01). Under appropriate supervision and monitoring, the physical therapy program for patients with leukemia and neuropathy treated regularly with vincristine displays major benefits that are able to be measured objectively by NCV studies.

Palabras llave : acute lymphoblastic leukemia; vincristine; peripheral nerves; nerve conduction velocity test; physical therapy.

        · resumen en Español     · texto en Español     · Español ( pdf )


Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons