Abstract

ROMANO-MAZZOTTI, Luis et al. Discordant response to highly active antiretroviral therapy in Mexican pediatric patients infected with HIV/AIDS. Bol. Med. Hosp. Infant. Mex. [online]. 2009, vol.66, n.4, pp.335-342. ISSN 1665-1146.

Introduction. The goal of antiretroviral (ART) therapy is to control human immunodeficiency virus replication and to increase CD4 T-cell count. Discordant response to ART occurs when only one of these two objectives is achieved. Methods. Pediatric patients who attended the Clínica de Inmunodeficiencias at Hospital Infantil de Mexico Federico Gomez were studied retrospectively. Response to a Pibased highly active antiretroviral therapy (HAART) was classified as optimal, failure, discordant response with viral failure and discordant response with viral success. Demographic data, viral load and CD4 T-cell count (baseline, 6-month and 12-month follow-up determinations) were analyzed. Results. Fifty six patients were included. Mean age of patients was 30.5 months. Discordant response was seen in 45 and 53.5% at 6- and 12-months follow-up, respectively. Conclusions. Discordant response was seen in >50% of our study population and is a common scenario; clinical implications are still unknown. Discordant response should not be interpreted, especially during the first 12 months of therapy, as a failure of HAART.

Keywords : Human immunodeficiency virus; pediatrics; infection; acquired immunodeficiency syndrome; antiretroviral treatment; discordant response.

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