Abstract

VILLALOBOS-ACOSTA, Claudia Patricia; PLASCENCIA-GOMEZ, Elsy Consuelo; ROMANO-MAZZOTTI, Luis  and  PAVIA-RUZ, Noris. Trends and survival in HIV-infected children and adolescents management with highly active antiretroviral therapy. Bol. Med. Hosp. Infant. Mex. [online]. 2009, vol.66, n.4, pp.314-324. ISSN 1665-1146.

Introduction. Since the introduction of highly active antiretroviral therapy (HAART), quality of life and survival of those persons infected by HIV, including children and adolescents, have improved substantially. Methods. This case study focuses on children <18 years old who were seen from April 1989 to December 2008 at the Immunodeficiency Clinic of the Hospital Infantil de Mexico Federico Gomez. Demographic data, infections, admissions and deaths were gathered. Results. 202 HIV-infected children and adolescents were seen under HAART or without HAART (>6 months). Of all patients, the time since diagnosis of acquired immunodeficiency syndrome (AIDS) was on average 37.3 months. Perinatal transmission was the most frequent mode in 96%. At diagnosis of AIDS, most patients were in an advanced stage of illness. The incidence rates of opportunistic infections decrease from 30.2 episodes per 100 person-years before HAART to 3.3 after initiation of HAART. Of patients receiving HAART, 95% had a survival >10 years. Conclusions. Management with HAART decreased incidence rates of infectious diseases, admissions and death in the population studied.

Keywords : Acquired immunodeficiency syndrome; HIV; infections; child; adolescents; survival; highly active antiretroviral therapy.

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