Resumo

JASSO-GUTIERREZ, Luis; CASTELLANOS-SOLIS, Estela Carolina  e  SANTOS-PRECIADO, José Ignacio. Importance of pharmacovigilance in the Mexican pediatric population. Bol. Med. Hosp. Infant. Mex. [online]. 2009, vol.66, n.3, pp.213-228. ISSN 1665-1146.

In order to emphasize the importance of pharmacovigilance in children, a review was carried out with special emphasis on general and conceptual aspects outlined in the Mexican Official Norm and other documents. The different classifications from the Adverse Drug Reactions (ADR) and Adverse Drug Events (ADE) are discussed. Using the data base of the WHO Collabotatory Center for Drugs International Monitoring, uppsala Monitoring Center (Sweden) we analyzed up to the year 2006 the present status of the ADR reports from 82 countries. Mexico ranks in the middle classified by age groups and number of reports in the data base. The impact of ADR stands out in the general population according to morbidity, mortality, sequealaes and cost considerations. The impact of ADE and ADR in new-borns and pediatric patients reports the experiences of international groups. Several recommendations are mentioned that will allow a system of pharmacovigilance to be established or improved for children in Mexico. The Hospital Infantil of Mexico has initiated an ambitious program.

Palavras-chave : Pharmacovigilance in children; adverse drug reactions reporting systems; drug monitoring; adverse drug effects.

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