Abstract

SANDOVAL-RAMIREZ, Eunice et al. Evaluation of anti-arrhythmic effect of propafenone in children with supraventricular paroxistic tachycardia. Bol. Med. Hosp. Infant. Mex. [online]. 2008, vol.65, n.2, pp.121-125. ISSN 1665-1146.

Introduction. Supraventricular tachycardia (SVT) involves arrhythmias treated with propafenone in children due to its utility. The aim of this study was to evaluate the anti-arrhythmic effect of propafenone as well as its pharmacokinetics in children with SVT. Methods. A prospective study was conducted in children with SVT. The evolution of their treatment with propafenone was followed by EKG monitoring. A pharmacokinetic study was carried out by using HPLC with fluorescence detection. Results. The files of 85 children with SVT from 2000 to 2007 were reviewed; currently 11 patients are treated with propafenone, Pharmacokinetics study was performed in 3 of the current patients. The EKG study showed regular registers after propafenone treatment. Propafenone pharmacokinetic parameters were similar to those reported previously. Conclusions. The patients included showed an arrhythmia remission, and their pharmacokinetic parameters were similar to those reported in the literature. Thus, the use of propafenone may be considered appropriate for SVT treatment in children.

Keywords : Anti-arrhythmic; cardiovascular; EKG; pharmacokinetics; propafenone; supraventricular tachycardia.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )