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Boletín médico del Hospital Infantil de México

versión impresa ISSN 1665-1146


SOTELO-CRUZ, Norberto; HURTADO-VALENZUELA, Jaime G.  y  RASCON-ALCANTAR, Adela. Stevens-Johnson syndrome: Report of 7 cases. Bol. Med. Hosp. Infant. Mex. [online]. 2005, vol.62, n.1, pp. 25-32. ISSN 1665-1146.

Introduction. Objective: the purpose of this study is to report on the evolution of 7 patients from Sonora Childrens Hospital (Hospital Infantil del Estado de Sonora) with Stevens-Johnson syndrome (SJS). Materials and methods. A retrospective chart review; we reviewed the clinical records of 7 patients hospitalized between 1978 and 2004 with a diagnosis of SJS. The variables were: age gender, place of origin, history of infection and prescription drug use prior to hospital admission and diagnosis; the signs and symptoms, laboratory and histologic features, treatment, complications and clinical course were evaluated. Results. Five male and 2 female patients were admitted with a clinical diagnosis of SJS during the period reviewed; 4 were under 5 years and 3 were adolescents, all had received drugs associated with SJS, The admission diagnosis of SJS was ascertained in 5 patients. All patients presented fever, at least 5 days, conjuntival secretion, dermal erythema and extend blisters, 2 children had signs and sympthoms of toxic epidermal necrolysis (TEN), the laboratory features were thrombocytopenia; the histological findings of skin biopsy were typical for SJS. Treatment: 3 patients received prednisone and blood transfusions, 1 child died as a complication of TEN. Conclusions. In this small series, SJS, showed a clinically variable course. Although there is no specific treatment, medical care should be similar to that of burn patients

Palabras llave : Stevens-Johnson syndrome; erythema multiforme; toxic epidermal necrolysis.

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