SciELO - Scientific Electronic Library Online

 
vol.87 número4Registro Nacional de Programas de Rehabilitación Cardiaca en México II (RENAPREC II)Orejuela izquierda en la enfermedad reumática mitral: principal fuente embolígena en la fibrilación auricular índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • No hay artículos similaresSimilares en SciELO

Compartir


Archivos de cardiología de México

versión On-line ISSN 1665-1731versión impresa ISSN 1405-9940

Resumen

FLORES-RAMIREZ, Ramiro et al. Global longitudinal strain as a biomarker in diabetic cardiomyopathy. A comparative study with Gal-3 in patients with preserved ejection fraction. Arch. Cardiol. Méx. [online]. 2017, vol.87, n.4, pp.278-285. ISSN 1665-1731.  http://dx.doi.org/10.1016/j.acmx.2016.06.002.

Objectives:

To establish a relationship between global longitudinal strain (GLS) and Galectin-3 in pre-clinical heart failure in diabetic patients. Galectin-3 is a biomarker in heart failure with depressed ejection fraction (HFdEF). The hypothesis is presented that Galectin-3 is related to GLS and can detect left ventricular dysfunction in heart failure with preserved ejection fraction.

Methods:

Galectin-3 and GLS were measured in 121 asymptomatic individuals: 14 diabetics with mild depressed ejection fraction (mdEF) (LVEF 47.0 ± 6.9); 76 diabetics with preserved ejection fraction (LVEF 61 ± 5.5), and 31 controls (61.7 ± 5.1).

Results:

Galectin-3 was elevated in all diabetics vs controls (3.46 ± 1.36 ng/ml vs 2.78 ± 0.91 ng/ml; p = .003). It was also elevated in mdEF (3.76 ± 1.12 ng/ml vs 2.78 ± 0.9 ng/ml; p = .009) and pEF subjects (3.41 ± 1.40 ng/ml vs 2.78 ± 0.9 ng/ml; p = .058), respectively, vs controls. No difference in Gal-3 was found between diabetic groups (p = .603). Diabetics had lower GLS than controls (–18.5 ± 3.9 vs –20 ± 2.6; p = .022). Diabetics with mdEF had lower GLS than those with pEF (–13.3 ± 3.41 vs –19 ± 3.2; P<.001). There was no difference in GLS with pEF compared to controls (–19.4 ± 3.2 vs –20 ± 2.6; p = .70).

Conclusions:

Galectin-3 is elevated in diabetic patients with mdEF, and is associated with a diminished GLS. GLS could be an early marker of left ventricular dysfunction as well as evidence of diabetic cardiomyopathy.

Palabras llave : Galectin-3; Global longitudinal strain; Diabetic cardiomyopathy; Mexico.

        · resumen en Español     · texto en Inglés     · Inglés ( pdf )