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Archivos de cardiología de México

On-line version ISSN 1665-1731Print version ISSN 1405-9940


TREJO-GUTIERREZ, Jorge F  and  LOPEZ-JIMENEZ, Francisco. Evidence-based cardiology: practical applications from epidemiology. I. The evaluation of a novel drug or therapy. Arch. Cardiol. Méx. [online]. 2011, vol.81, n.1, pp.47-52. ISSN 1665-1731.

The substantial increase of randomized controlled trials demand familiarity with the essential aspects of their design and performance by the cardiologist, particularly the adequate interpretation and applicability of the results. In this clinically-based review, we discuss some important aspects in the assessment of novel contemporary therapy such as the use and analysis of composite endpoints; implications from early termination of trials and extrapolation of results to the population.

Keywords : Randomized controlled trial; Critical analysis; Novel therapy; USA.

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