Resumo

ALEXANDERSON ROSAS, Erick et al. Endothelial function assessment by positron emission tomography in patients with hypercholesterolemia. Arch. Cardiol. Méx. [online]. 2008, vol.78, n.2, pp.139-147. ISSN 1665-1731.

Hypercholesterolemia prompts to endothelial dysfunction (ED) and ED predisposes to atherogenesis. ED appears early in the course of atherogenesis and it is considered a coronary artery disease (CAD) marker. Objectives: To assess endothelial function (EF) using Positron Emission Tomography (PET) in asymptomatic patients with recent dyslipidemia diagnosis and without history of ischemic heart disease and previous hypolipemiant treatment. Material and methods: Fourteen asymptomatic patients with recent dyslipidemia diagnosis (< 6 months) were studied by obtaining a lipid profile, blood glucose, and a three phase ¹³N-ammonia PET scan: rest, cold pressortest (CPT) and pharmacologic stress with adenosine. EF was assessed by calculating the coronary flow reserve (CFR), endothelial-dependant vasodilatation index (EDVI), and coronary blood flow increase percentage in CPT (% Δ CF). Results: 79% of patients with dyslipidemia had ED and all their values were lower than those previously published as normal: rest coronary flow 0.44 ± 0.12 vs 0.57 ± 0.147 (p = 0.002), CPT coronary flow 0.57 ± 0.17 vs 0.88 ± 0.26 (p = 0.001), stress coronary flow 1.24 ± 0.05 vs 1.81 ± 0.35 (p = 0.005), EDV11.28 ± 0.25 vs 1.53 ± 0.24 (p 0.017), CRF 2.79 ± 0.94 vs 3.15 ± 0.48 (p 0.198) and % Δ CF 29.08 ± 24.62% vs 53 ± 24.60% (p 0.022). Conclusions: Asymptomatic patients in early stages of dyslipidemia showed a greater ED prevalence that was detected by ¹³N-ammonia PET scan.

Palavras-chave : Positron emission tomography; Endothelial dysfunction; Dyslipidemia.

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