Archivos de cardiología de México
versión impresa ISSN 1405-9940
ALEXANDERSON ROSAS, Erick et al. A method designed for the assessment of myocardial metabolism in rats with 18F-FDG using small-animal-PET: Initial experience in Mexico. Arch. Cardiol. Méx. [online]. 2008, vol.78, n.1, pp. 11-18. ISSN 1405-9940.
Purpouse: To standarize an acquisition protocol for the study of myocardial metabolism in adult rats. Material and methods: Three Wistar adult male rats were studied in three different protocols: no fasting group, fasting group over a period of 12 hr before the study with only water provided ad libitum, and fasting group by the same time receiving an oral 50% glucose solution. Thirty-minute acquisition images were obtained with a micro-PET, thirty and sixty minutes after the administration of 370 - 555 MBq 18F-FDG. Comparative and visual analysis were performed by two experts in the field. Results: Eigtheen studies were analyzed, six per group. The best images were those of the fist group, especially those taken at 60 minutes after the 18F-FDG administration. Conclusion: It is possible to establish the non-fasting protocol for the assessment of myocardial metabolism to be used in the future for the myocardial viability evaluation in ischemic cardiopathy.
Palabras llave : 18F-FDG; MicroPET; Myocardial viability.