Serviços Personalizados
Journal
Artigo
Indicadores
- Citado por SciELO
- Acessos
Links relacionados
- Similares em SciELO
Compartilhar
TIP. Revista especializada en ciencias químico-biológicas
versão impressa ISSN 1405-888X
Resumo
VEGA-BADILLO, Joel. Dysregulation in hepatic cholesterol homeostasis and its implications in nonalcoholic steatohepatitis. TIP [online]. 2017, vol.20, n.1, pp.50-65. ISSN 1405-888X. https://doi.org/10.1016/j.recqb.2016.11.005.
Several studies have shown that hepatic free cholesterol (FC) has an important role in the pathogenesis of nonalcoholic steatohepatitis (NASH). These studies have provided evidence that hepatic FC accumulation is toxic at different levels including: mitochondrial oxidative injury, endoplasmic reticulum (ER) stress, and activation of Kupffer cells (KCs) and hepatic stellate cell (HSCs). Altogether, this suggests that hepatic FC content is important for the initiation, maintenance and modulation of the inflammatory response associated with NASH. In this review several mechanisms that participate in the regulation of cholesterol homeostasis and their possible implications in the development and progression of nonalcoholic fatty liver disease (NAFLD) are discussed.
Palavras-chave : free cholesterol; NASH; fibrosis; NAFLD; homeostasis.