Abstract

LARIZA ANDRADE-GUEL, Marlene; LOPEZ-LOPEZ, Lluvia Itzel  and  SAENZ-GALINDO, Aidé. Synthesis, IR characterization and preliminary antibacterial evaluation of 2-(amine)-l,4-naphthoquinone derivatives. TIP [online]. 2011, vol.14, n.2, pp.75-82. ISSN 1405-888X.

Naphthoquinones are compounds of natural or synthetic origin which have shown important biological activities, as antibacterial, antifungal, antimalarial and anticancer agents. This paper reports the 2-(amine)-1,4-naphthoquinone synthesis using different methods such as the room temperature synthesis (RTS), conventional heating synthesis (CCS) and ultrasound-assisted synthesis (UAS). Characterization was performed by infrared spectroscopy. in addition, antibacterial capacity was also determined against proteus sp. and Enterococcus faecalis strains. The 2-benzylamine-1,4-naphthoquinone derivative showed the highest activity.

Keywords : 1,4-naphthoquinone; antibacterial agent; ultrasound.

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