Resumo

AVELINO-FLORES, M.C.G.; BIBBINS-MARTINEZ, M.D.; VALLEJO-RUIZ, V.  e  REYES-LEYVA, J.. In vitro evaluation of cytotoxic and antitumor activity of medicinal plants recommended in Cuetzalan del Progreso, Puebla, Mexico. Polibotánica [online]. 2019, n.47, pp.113-135. ISSN 1405-2768.  https://doi.org/10.18387/polibotanica.47.9.

Plants have been used since ancient times as a source of medicines, some active ingredients with pharmacological activity have been successfully obtained from these, traditional known about their use have served to treat diversity of diseases. Mexican plants (Costus pulverulentus, Sechium edule, Tabernaemontana alba and Vernonia patens) used in Mexican traditional medicine and recommended by people of Cuetzalan del Progreso, Puebla, were collected, aqueous and hydroalcoholic extracts were produced and their capacity to inhibit both the proliferation and tumor growth was evaluated in vitro using the human cervical cancer SiHa cell line. Two types of assays were performed: a) Inhibition of cell proliferation and b) Tumor size reduction in vitro. Hydroalcoholic extracts of all the plants and the aqueous extract of S. edule and T. alba inhibited cell proliferation. S. edule hydroalcoholic extract of aerial parts showed the highest inhibitory activity at the smallest concentrations with IC50 of 16.5 µg/mL. All hydroalcoholic extracts and the aqueous extract of T. alba reduced the size of tumors formed in vitro. The hydroalcoholic extract of V. patens showed the highest inhibitory activity 40.5% at 1 µg/mL. Contradictory results were observed with V. patens extracts, the aqueous extracts increased tumor size, whereas the hydroalcoholic extract showed the highest inhibitory activity.

Palavras-chave : traditional medicine; Cuetzalan; cytotoxic activity.

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