Resumo

VILLA-DE LA TORRE, Fabiola et al. Anti-inflammatory activity of critonia aromatisans and montanoa grandiflora leaves extracts, plants used in mayan traditional medicine to treat inflammation. Polibotánica [online]. 2017, n.43, pp.285-319. ISSN 1405-2768.  https://doi.org/10.18387/polibotanica.43.13.

The aim of the study is to investigate anti-inflammatory properties of polar and non-polar extracts prepared from Critoniaaromatisansand Montanoa grandiflora, two common native species used in Mayan traditional ointments to treat inflammation, joint pain and rheumatism. The antiinflammatory properties of methanol/acetonitrile and n- hexane leaf extracts were tested in vivo and in vitro. The extracts of C. aromatisansand M. grandiflora decreased in a concentration-dependent manner lipopolysaccharide (LPS)-induced nitric oxide (NO) production without affecting the cell viability. The extracts of C. aromatisansat dose of 200 mg/kg exhibited substantial anti-inflammatory activity in the carrageenaninduced paw oedema test and 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced ear oedema inhibition assay with a reduction in inflammation of up to 90 and 80%, respectively. These results validate the traditional uses by Mayan communities that endorse the use of this species to treat inflammation.

Palavras-chave : Critonia aromatisans; Montanoa grandiflora; inflammation; carrageenan; nitric oxide; macrophages.

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