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Revista de la Sociedad Química de México
versão impressa ISSN 0583-7693
Resumo
GONZALEZ-MORALES, Angelina; FERNANDEZ-ZERTUCHE, Mario e ORDONEZ, Mario. Simultaneous Separation and Assignment of Absolute Configuration of γ-Amino-β-Hydroxyphosphonates by NMR Using (S)-Methoxyphenylacetic Acid (MPA). Rev. Soc. Quím. Méx [online]. 2004, vol.48, n.4, pp.239-245. ISSN 0583-7693.
γ-(N,N-disubstituted)amino-β-hydroxypropylphosphonates are important intermediates in the preparation of enantiomerically pure γ-amino-β-hydroxypropylphosphonic acid (GABOBP), an analogue of γ-amino-β-hydroxybutyric acid (GABOB), which acts in a variety of clinical conditions including schizophrenia, epilepsy, and other character-based disorders including severe convulsions. The synthesis of γ-amino-β-hydroxypropylphosphonic acid (GABOBP) enantiomerically pure is now an area of great interest, and for this reason, a variety of synthetic routes have been developed.
Palavras-chave : γ-amino-β-hydroxypropylphosphonic acid (GABOBP); assignment of absolute configuration; (S)-methoxyphenylacetic acid (MPA).