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Revista de la Sociedad Química de México

Print version ISSN 0583-7693


GARDUNO-RAMIREZ, María Luisa  and  DELGADO, Guillermo. New Eremophilanoids from the Roots of Psacalium radulifolium: Hypoglycemic, Antihyperglycemic and Anti-Oxidant Evaluations. Rev. Soc. Quím. Méx [online]. 2003, vol.47, n.2, pp.160-166. ISSN 0583-7693.

The investigation of the chemical constituents from the roots of Psacalium radulifolium (Compositae), a member of the matarique complex of medicinal plants, resulted in the isolation of four additional new eremophilanoids: radulifolin D, radulifolin E (ketodecompostin), radulifolin F (3β-hydroxycacalone-3-O-β-D-glucopyranoside) and epi-radulifolin F (3β-hydroxy-6-epi-cacalone-3-O-β-D-glucopyranoside), together with the known compounds maturinone, acetylmaturine, dimaturine, triacontanol, hydroxycacalolide, epi-hydroxycacalolide, β-sitosteryl-3-O-β-D-glucopyranoside, β-D-glucopyranose and saccharose. The methanol extract from the roots of this species displayed hypoglycemic activity, but cacalol, cacalone, epi-cacalone, O-methyl-1,2-dehydrocacalol and decompostin did not exhibit activity. The antihyperglycemic evaluation of the extract demontrated that it was inactive. Some isolated compounds were also tested for antioxidant activity, and cacalol was found to be active.

Keywords : Psacalium radulifolium; Compositae; matarique; radulifolin D; radulifolin E; radulifolin F; epi-radulifolin F; eremophilanoids; hypoglycemic activity; antihyperglycemic activity; anti-oxidant activity.

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