Abstract

CUEVAS, F. et al. In vivo analysis of the genotoxic potential of 14-Hydroxylunularin, a molecule with leishmanicidal effect. Rev. latinoam. quím [online]. 2011, vol.39, n.3, pp.100-106. ISSN 0370-5943.

In this study, we evaluated whether 14-hydroxilunularin, a hydroxyibibenzyl derivative that showed in vivo and in vitro leishmanicidal activity, has genotoxic effects in bone marrows of treated mice by analyzing the percentages of chromosomal aberrations (CA) in metaphasic cells and micronucleated polychromatic erythrocytes (MNPCE). The frequencies of CA in bone marrow cells of the mice treated with three different concentrations of 14-hydroxylunularin were not statistically significant when compared with the negative control group. The frequencies of MNPCE in bone marrow cells of mice treated with three different concentrations of 14-hydroxylunularin were similar to the frequency found in the negative control group. The results indicate that the 14-hydroxylunularin does not induce an increase of cytogenetic damage in bone marrow cells of mice exposed to the same, treated for 48 hours.

Keywords : 14-hydroxilunularin; leishmanicidal; genotoxic; chromosomal aberrations; micronucleated polychromatic erythrocytes; urethane.

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