Abstract

MARTINEZ-LUIS, Sergio; BALLESTEROS, Javier  and  GUTIERREZ, Marcelino. Antibacterial constituents from the octocoral-associated bacterium Pseudoalteromonas sp.. Rev. latinoam. quím [online]. 2011, vol.39, n.1-2, pp.75-83. ISSN 0370-5943.

Bioassay guided fractionation of the ethyl acetate extract obtained from the bacterium Pseudoalteromonas sp. isolated from the octocoral Leptogorgia alba led to the isolation of two known diketopiperazines identified as cyclo-(L-Ph-L-Pro) (1), and cyclo-(L-Leu-L-Pro) (2). Structures of 1-2 were defined based on their spectroscopic data, including NMR, HRESITOF-MS and optical rotations, and their comparison with the spectroscopic data reported in the literature. Both, compounds 1 and 2 showed strong inhibition on the growth of Bacillus subtillis and Vibrio sp. Analysis of the crude extract using APCI-MS revealed the presence of other compounds of the diketopiperazine family.

Keywords : Pseudoalteromonas sp.; Bacillus subtilis; Vibrio sp.; diketopiperazines; antibiotics.

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