Resumen

GONZALEZ-TRUJANO, Ma. Eva  y  NAVARRETE, Andrés. Effect of zinc on the cadmium acute intoxication in the gastric injury induced in rats. Rev. latinoam. quím [online]. 2011, vol.39, n.1-2, pp.45-54. ISSN 0370-5943.

Cadmium is a toxic heavy metal that has been implicated in dysfunction of several tissues. However, its effect in gastric injury is not completely understood. The aim of this study was to investigate the consequence of the acute intoxication with CdCl₂ in gastric ulcer induced by several experimental models. CdCl₂ administration (1.2, 2.4, 4.8 and 9.6 mg/kg) increased the ulcer index in a dose-dependent fashion through the induction by absolute ethanol (230%), indomethacin plus histamine (280%), acidified acetylsalicylic acid (330%) and 0.6 N HCl (350%). Absolute ethanol induced the minor severity of gastric injury; therefore it was selected to compare the ZnCl₂ antiulcer effect in presence of cadmium. Administration of ZnCl₂ (5, 10, 20, 40, 80 mg/kg, s.c.) decreased in a dose-dependent manner the ethanol-induced ulcer index, whereas CdCl₂ (1.2, 2.4 and 4.8 mg/kg, s.c.) increased the ethanol-induced gastric damage. Pretreatment with ZnCl₂ at 20 mg/kg completely prevented the ethanol-induced damage increase produced by CdCl₂. These results suggest the important participation of an environmental contaminant like cadmium in the development of the gastric ulcer, but also, the mechanism of action of this methal might be associated with the zinc targets.

Palabras llave : cadmium chloride; zinc chloride; ulcer; ulcer rat models; toxicity.

        · resumen en Español     · texto en Inglés     · Inglés ( pdf )