Resumen

SAGANUWAN, Saganuwan Alhaji; ONYEYILI, Patrick Azubuike; AMEH, Egoohe George  y  UDOK ETUK, Emmanuel. In vivo antiplasmodial activity by aqueous extract of Abrus precatorius in mice. Rev. latinoam. quím [online]. 2011, vol.39, n.1-2, pp.32-44. ISSN 0370-5943.

Antimalarial activity of aqueous extract of Abrus precatorius leaf was studied in Swiss albino mice. Thirty-six (36) mice of either sex that weighed 20.61 ± 3.63g were separated into six groups of six mice each. Five groups were intravenously inoculated 10⁷ Plasmodium berghei per gram body weight. The sixth group was neither infected nor treated. Three days post infection, four groups were administered orally with 25, 50 and 100mg/kg of the extract and 25mg/kg of halofantrine for five consecutive days, whereas the fifth group was not treated. The results revealed significant (P<0.05) clearance of P. berghei from the groups administered with 25, 50 and 100mg/kg of the extract, and 25mg/kg of halofatrine respectively on 14th day of infection. The infected untreated group showed significant level of parasitaemia up till 14^th day of infection. There were significant (P<0.05) decreased levels of mean weight gain, mean erythrocytes count, mean packed cell volume, mean haemoglobin concentration, mean corpuscular volume and mean corpuscular haemoglobin. However, Mean corpuscular haemoglobin concentration and mean white blood cells increased significantly in infected untreated group (P<0.05). Three animals died from each of the groups treated with 25 and 100mg/kg of the extract. While one animal died from the infected untreated group and the halofantrine treated group. Hence, the extract show potential antiplasmodial activity on P. berghei ,the death of animals in the experimental groups may be due to toxicity of Abrus leaf, halofantrine and P. berghei respectively.

Palabras llave : Antiplasmodial activity; Abrus precatorius leaf; halofantrine; Mus musculus; Plasmodium berghei; toxicity.

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