OBJECTIVE:

To determine and compare long-term creatinine clearance with baseline creatinine clearance in patients with obstetric hemorrhage.

MATERIALS AND METHODS:

Observational, longitudinal, retrospective, comparative and analytical study carried out in a series of patients with obstetric hemorrhage (loss ≥ 1000 mL) hospitalized in the intensive care unit. Creatinine clearance was calculated with the CKD-EPI formula at two time points: on admission to intensive care after the end of pregnancy complicated by hemorrhage (baseline measurement) and from their last recorded medical consultation (long-term measurement). Descriptive statistics and Student&apos;s t-test were used with SPSS version 20, p < 0.05 was considered significant.

RESULTS:

Forty-nine patients with mean age of 30.48 ± 6.06 years and 32.20 ± 8.24 weeks of pregnancy were studied. Cesarean section was performed in 39 of 49, 5 of 49 delivered, 4 of 49 required hysterotomy and only one required instrumental curettage. The mean estimated bleeding was 2744.89 ± 1474.65 mL. Creatinine clearance: initial measurement 159.09 ± 46.62 and long-term (22.27 ± 1.55 months later) 112.23 ± 30.91 mL of min of 1.73 m2 body surface area. The difference was significant (p = 0.002). On long-term measurement, chronic kidney disease was found in 1 of the 49 patients.

CONCLUSIONS:

Long-term creatinine clearance resulted lower, perhaps due to regression of gestational changes over time, but without significant functional impairment, except for one case with chronic kidney disease found as a finding not necessarily related to obstetric hemorrhage.

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