OBJECTIVE:

To compare the frequency and clinical characteristics of acute kidney injury in patients with early and late-onset severe preeclampsia.

MATERIALS AND METHODS:

Observational, longitudinal, retrospective, comparative and analytical study carried out in a series of 250 pregnant patients with SP from the Intensive Care Unit. With the cut-off point of 34 gestational weeks, two study groups were formed: group A 130 patients with early-onset SP (< 34 weeks) and group B, 120 women with late-onset severe preeclampsia (≥ 34 weeks). The frequency of acute kidney injury on admission and discharge from the Intensive Care Unit (defined as serum creatinine value ≥ 1.1 mg/dL) and its clinical characteristics (hourly diuresis, replacement therapy and outcome) were compared. Descriptive and inferential statistics were used (Student’s t tests, U Mann Whitney and χ2), p ≤ 0.05 was significant. The SPSS 20 program was used.

RESULTS:

Group A: acute kidney injury at admission 9.6% (n = 24, creatinine 1.20 ± 0.14 mg/dL) and discharge 12% (n = 30, creatinine 1.20 ± 0.13 mg/dL) (p = 0.930). Group B admission 10.8% (n = 27, creatinine 1.32 ± 0.39 mg/dL) and discharge 12% (n = 30, creatinine 1.32 ± 0.31 mg/dL) (p = 0.920). There was no intergroup difference in creatinine on admission (p = 0.156), but there was on discharge in favor of group B (p = 0.009). Hourly diuresis was similar (p = 0.224), replacement therapy 0% and outcome with improvement of acute kidney injury 24% (group A n = 30, group B n = 30).

CONCLUSIONS:

The frequency and clinical characteristics of acute kidney injury in pregnant patients with early and late-onset severe preeclampsia were similar.

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