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Ginecología y obstetricia de México
versão impressa ISSN 0300-9041
Resumo
CALVA-ESPINOSA, DY et al. Comparison of automated platforms for the HPV genotypification. Ginecol. obstet. Méx. [online]. 2017, vol.85, n.9, pp.569-577. ISSN 0300-9041.
OBJECTIVE:
To compare operative performance and concordance of human papillomavirus genotyping results obtained on Cobas® 4800 and BD Viper™ LT automated systems from liquid-based cytology samples.
MATERIALS AND METHODS:
Retrospective study in 1964 women attending the clinics of Salud Digna para todos I.A.P. from April to June 2016 to perform the Papanicolaou study; samples were stored in the BD SurePath™ liquid-based cytology collectors. The Cobas® 4800 and BD Viper™ LT systems were used for virus genotyping. The results were analyzed with the Pearson χ2 test, and concordance was obtained using the Cohen Kappa index.
RESULTS:
1934 of liquid-based cytology samples were analyzed on the Cobas® 4800 and BD Viper™ LT platforms. The concordance between the results obtained by both platforms was very high (κ = 0.832). Moreover, there are differences between the number of positive and negative results reported, as well as in the proportions of the different genotypes, however, these were not statistically significant.
CONCLUSION:
There are no significant differences between the results obtained for the detection of the human papillomavirus obtained by the Cobas® 4800 and BD Viper™ LT platforms. However, at the operational level, there are important differences that must be taken into account when implementing any of these platforms.
Palavras-chave : Cervical Cancer; Cobas® 4800; BD Viper™ LT; Human Papilloma Virus.