SciELO - Scientific Electronic Library Online

 
vol.25 número1Variación fitoplanctónica en un lago urbano del municipio de Cuernavaca, Morelos, MéxicoFrecuencias de riego, compactación, porosidad aerífera y tensión cortante del suelo relacionadas con el desarrollo radical de soya índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • No hay artículos similaresSimilares en SciELO

Compartir


Acta universitaria

versión On-line ISSN 2007-9621versión impresa ISSN 0188-6266

Resumen

SANTOSH KUMAR, Badampudi et al. Synthesis, characterization and in vitro santimicrobial evaluation of sulphonyl urea derivatives as potential inhibitors of beta-ketoacyl-acyl carrier protein synthase III (FabH). Acta univ [online]. 2015, vol.25, n.1, pp.12-21. ISSN 2007-9621.  http://dx.doi.org/10.15174/au.2014.658.

A series of 15 sulphonyl urea derivatives (7a-7o) containing various heterocyclic substituents were synthesized, characterized by elemental analysis, IR, 1H NMR and 13C NMR spectra and evaluated for in vitro antibacterial and antifungal activity. Molecular docking studies were performed to calculate docking scores and to propose the binding mode of sulphonyl urea derivatives with E. coli beta-ketoacyl-acp synthase III, a key enzyme that catalyzes the initial step of fatty acid biosynthesis via a type II dissociated fatty acid synthase. The results from this study revealed that the derivatives 7g, vj, 7l and 7o can become possible lead molecules for antimicrobial drug discovery. In vitro antimicrobial studies confirmed that the derivatives 7g, 7j, 7l and 7o have demonstrated better activity than the others.

Palabras llave : β-ketoacyl-acyl carrier protein synthase III (FabH); sulphonyl urea derivatives characterization; antimicrobial activity; in vitro; in silico.

        · resumen en Español     · texto en Inglés     · Inglés ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons