Resumen

GRANADOS-GARCIA, Isis Beatriz et al. Paraoxonase 1 and its relationship with risks factors in fumigators of the Guerrero State: Preliminary study. Rev. Int. Contam. Ambient [online]. 2022, vol.38, 54224.  Epub 28-Feb-2023. ISSN 0188-4999.  https://doi.org/10.20937/rica.54224.

Organophosphate pesticides (OP) are widely used for the control of pests and vector-borne diseases by state and national governments. However, these compounds can cause acute and chronic intoxication, and diverse factors play a relevant role in their toxicity. One such factor is paraoxonase 1 (PON1), a protein that hydrolyzes OP and protects the body from toxicity. The objective of this study was to assess the serum concentration of PON1 and its relationship with risk factors in a population of fumigators from the state of Guerrero, in Mexico. A cross-sectional study was conducted with 67 fumigators and a control group of 46 non-fumigators. A survey instrument was applied to capture the labor practices and pesticides used, and anthropometric and biochemical measurements were determined. Serum concentration of PON1 was quantified by enzyme-linked immunoassay (ELISA). The results show that most of the fumigators use carbamates (38 %) and OP (32 %) pesticides. The PON1 concentrations were 21.2 ng/mL in the fumigators vs. 18.7 ng/ml in the control group. We also found that body mass index, diabetes history, time in years that the worker reports carrying out the pesticide fumigation, the number of pesticides used, and the consumption of alcohol, vitamins and food supplements were risk factors associated with PON1 concentration shifts. It is necessary to consider the intrinsic and extrinsic factors of individuals when evaluating PON1 levels in populations exposed to pesticides.

Palabras llave : PON1; pesticides; vector management; body mass index; time of fumigation.

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