Abstract

JAUREGUI RUIZ, Oddir; GALVAN GARCIA, Eduardo  and  MACHAIN LEYVA, Cyntia Zulema. Association Levels of brain natriuretic peptide with morbidity and mortality in infective endocarditis. Rev. Mex. Cardiol [online]. 2013, vol.24, n.4, pp.196-204. ISSN 0188-2198.

Infective endocarditis (IE) is an infection with high morbidity and mortality. Identify patients with increased risk for complications, provides the opportunity to establish an aggressive therapeutic. B-type natriuretic peptide is a quick, available and high levels has been linked with poor outcome in IE. Objectives: To determine the association between B-type natriuretic peptide levels and morbidity and mortality in patients with infective endocarditis. Material and methods: We included patients ≥ 15 years, during the period July 2010 to July 2012. They were divided into groups based on the levels of B-type natriuretic peptide, group 1 B-type natriuretic peptide < 400 pg/mL, group 2 B-type natriuretic peptide ≥ 400 < 1,000 pg/mL and group 3 ≥ 1,000 pg/mL. The association between elevated B-type natriuretic peptide and a composite outcome of death and embolic was evaluated as a primary endpoint and these components individually as a secondary points. Descriptive statistics were employed measures of central tendency and dispersion. Statistical significance was evaluated using p Pearson and χ² test. Results: We included 57 patients, 23 (40.4%) in the group 1; 21 (36.8%) to group 2, and 13 (22.8%) in the group 3. The primary point (composite of death and embolic events) was higher in group 3 (57.1%) compared with group 1 (0%) and 2 (42.9%), p = 0.024. The secondary endpoints evaluated individually, in-hospital mortality was higher in group 3 (75%), p < 0.0001. Late mortality was present in one patient in group 2, p = 0.41. Embolic events were more frequent in group 2 (57.9%) p = 0.020. Conclusions: This study demonstrates the association between elevated B-type natriuretic peptide and increased morbidity and mortality in patients with infective endocarditis.

Keywords : Infective endocarditis; brain natriuretic peptide; embolic events.

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