SciELO - Scientific Electronic Library Online

vol.19 issue3Increase of myeloperoxidase activity in patients with asthma associated to diabetes mellitus type 2. An indicator of homeostatic disequilibriumCost-effectiveness of diagnostic methods for tuberculosis author indexsubject indexsearch form
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • Have no similar articlesSimilars in SciELO


Revista del Instituto Nacional de Enfermedades Respiratorias

Print version ISSN 0187-7585


TORRES-RAMOS, Yessica Dorin; SIERRA-VARGAS, Martha Patricia; OLIVARES-CORICHI, Ivonne María  and  HICKS GOMEZ, Juan José. Plasma markers of oxidative stress in healthy 31-60 year old mexican population. Rev. Inst. Nal. Enf. Resp. Mex. [online]. 2006, vol.19, n.3, pp.206-213. ISSN 0187-7585.

Introduction: Patients with asthma, COPD, diabetes mellitus, kidney diseases and Alzheimer syndrome, conditions associated to oxidative stress, have modifications and rupture of certain plasma biomolecules. In order to explain properly this findings, basal values in normal individuals of such biomolecules should be known. Objective: To determine the basal values of some markers of oxidative stress in healthy 31 to 60 year old individuals. Method: Seventy seven healthy volunteers were classified into group 1, 31 to 40 years, group 2, 41 to 50 years and group 3, 51 to 60 years; the following oxidative stress markers were measured: reactive compounds to tiobarbituric acid (TBARs), predisposition to oxidative stress, determination of carbonil groups, total antioxidative capacity of plasma (TACP) and enzymatic activity of paraoxonase. ANOVA and Bonferroni tests were used; a level of 0.05 was considered significant. Results: Croup 2 and 3 showed significant increment in TBARs (8.462 ± 0.571 vs 10.34 ± 1.23µM TBARs, respectively). In the predisposition to lipoper oxidation, group 3 was more susceptible, due to an increase in RCTA levels (477.0 ± 16.71 µM) in comparison to group 2 (432.3 ± 25.71 µM) and 1 (320.6 ± 28.95 µM). There was no difference in the determination of carbonil groups between the groups. TACP is significantly diminished in group 2 in relation to group 1 (0.950 ± 0.071 vs 0.69 ± 0.068 units, respectively). Paraoxonase's activity showed a significant increase in group 3 in relation to group 1 (0.119 ± 0.004 vs 0.072 ± 0.007 nmol p-nitrophenol/mg protein, respectively). Conclusion: Advancing age modifies biomolecular markers of oxidative stress; during the natural aging process, the main damage is to lipids.

Keywords : Oxidative stress; reactive oxygen species; antioxidant capacity; protein oxidation; lipoperoxidation.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License