Abstract

GOROCICA, Patricia et al. Structural components of the envelope of Mycobacterium tuberculosis that intervene in the pathogenesis of tuberculosis. Rev. Inst. Nal. Enf. Resp. Mex. [online]. 2005, vol.18, n.2, pp.142-153. ISSN 0187-7585.

The glycosylated compounds of Mycobacterium tuberculosis envelope play an important role in the immunopathogenesis of tuberculosis. These molecules are involved in the binding to the host cell surface followed by their internalization and persistence in macrophages; likewise they take part in the macrophage's activation and the production of cytokines that are relevant during the immune response against mycobacteria. In this review we examine the molecular characteristics of the main mycobacterial cell surface saccharide structures and their relation with the modulation of the immune response to tuberculosis.

Keywords : Mycobacterium tuberculosis; immunopathogenesis of tuberculosis; mycobacterial glycoconjugates; saccharide molecular characteristics.

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